REACTION OF PYRYLIUM-SALTS WITH NUCLEOPHILES .23. TRIARYLETHENE DERIVATIVES CONTAINING AN OXYALKYLENEAMINO OR OXYALKYLENE-N-PYRIDINIUM SIDE-CHAIN

Authors
STANCIUC O BALABAN AT
Citation
O. Stanciuc et At. Balaban, REACTION OF PYRYLIUM-SALTS WITH NUCLEOPHILES .23. TRIARYLETHENE DERIVATIVES CONTAINING AN OXYALKYLENEAMINO OR OXYALKYLENE-N-PYRIDINIUM SIDE-CHAIN, Journal of pharmaceutical sciences, 82(9), 1993, pp. 927-933
Citations number
44
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical sciences → ACNP
ISSN journal
00223549
Volume
82
Issue
9
Year of publication
1993
Pages
927 - 933
Database
ISI
SICI code
0022-3549(1993)82:9<927:ROPWN.>2.0.ZU;2-C
Abstract
A synthetic design was devised for preparing primary amines related to anticancer drugs clomiphene and tamoxifen on the basis of key interme diates with a phenolic group, to which a side chain (omega-aminoethoxy or omega-aminopropoxy) was attached. These compounds were then reacte d with 2,4,6-trimethyl- or 2,4,6-triphenylpyrylium salts.1 This afford ed pyridinium analogues of clomiphene and tamoxifen as potential thera peutic agents for treatment against hormone-dependent tumors.