INVESTIGATION OF CELL-ENVELOPE DAMAGE TO PSEUDOMONAS-AERUGINOSA AND ENTEROBACTER-CLOACAE BY DIBROMOPROPAMIDINE ISETHIONATE

Authors
RICHARDS RME XING JZ GREGORY DW MARSHALL D
Citation
Rme. Richards et al., INVESTIGATION OF CELL-ENVELOPE DAMAGE TO PSEUDOMONAS-AERUGINOSA AND ENTEROBACTER-CLOACAE BY DIBROMOPROPAMIDINE ISETHIONATE, Journal of pharmaceutical sciences, 82(9), 1993, pp. 975-977
Citations number
9
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical sciences → ACNP
ISSN journal
00223549
Volume
82
Issue
9
Year of publication
1993
Pages
975 - 977
Database
ISI
SICI code
0022-3549(1993)82:9<975:IOCDTP>2.0.ZU;2-V
Abstract
Electron micrographs of log-phase Pseudomonas aeruginosa and Enterobac ter cloacae cultured for 4 h in the presence of subinhibitory concentr ations of dibromopropamidine isethionate indicate that this antibacter ial agent can cause marked damage to the cell envelope structures of b oth species. This result provides an explanation of how dibromopropami dine can enhance the uptake and thus the activity of a second antibact erial agent used in combination with it.