EVALUATION OF THE EFFECT OF LOW-MOLECULAR CHITOSAN ON THE SOLUBILITY AND DISSOLUTION CHARACTERISTICS OF SPIRONOLACTONE

Authors
ACARTURK F SENCAN A CELEBI N
Citation
F. Acarturk et al., EVALUATION OF THE EFFECT OF LOW-MOLECULAR CHITOSAN ON THE SOLUBILITY AND DISSOLUTION CHARACTERISTICS OF SPIRONOLACTONE, Die Pharmazie, 48(8), 1993, pp. 605-607
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
48
Issue
8
Year of publication
1993
Pages
605 - 607
Database
ISI
SICI code
0031-7144(1993)48:8<605:EOTEOL>2.0.ZU;2-P
Abstract
The effect of the low-molecular chitosan on the solubility and dissolu tion characteristics of spironolactone has been studied. Kneaded mixtu res of spironolactone with low-molecular chitosan were prepared and th eir in vitro dissolution behaviours were examined. The interaction of spironolactone with low-molecular chitosan both in aqueous solution an d in the solid state was examined by performing solubility analysis, p owder X-ray diffractometry and differential scanning calorimetry measu rements. It was found that low-molecular chitosan may be used for the enhancement of the dissolution rate of spirono-lactone.