EVALUATION OF PARTITIONING AND SOLUBILITY DATA FOR SOME GUANINE DERIVATIVES IN TERMS OF MUTUAL MISCIBILITY OF OCTANOL AND WATER PHASE

It has been previously demonstrated that deoxyaciclovir has a higher p artition coefficient in octanol/water and is also more soluble in the aqueous phase than aciclovir. Intermolecular interactions or solvate f ormation have been suggested as a possible reason for this contradicti on [1, 2]. Using UV-VIS spectrophotometry and the partition method we showed that the three tested guanine derivatives aciclovir, deoxyacicl ovir and N2-acetylaciclovir do not interact in aqueous and octanol sol utions. The mentioned higher lipophilicity and better water solubility for deoxyaciclovir as well as the differences in solubility values we re explained by means of mutual water/octanol saturation.