Milky spots (MS), considered by the authors as a Coelomatic Lympho-mye
lopoietic Organ (CLMO), present a strong reactivity during experimenta
l schistosomal mansoni infection, characterized by an increase of lymp
hocytes, macrophages, plasmocytes, mast cells, neutrophils and express
ion of eosinophil metaplasia. Intraperitoneal injection of purified Sc
histosoma mansoni (Sm) eggs provoked a rise in the number and size of
MS, which developed the sessile marginal and pedunculated types. The a
uthors conclude that egg antigens are, at least partially, responsible
for MS reactivity during Sm infection.