V. Deubel, RECENT ADVANCES AND PROSPECTIVE RESEARCHES ON MOLECULAR EPIDEMIOLOGY OF DENGUE VIRUSES, Memorias do Instituto Oswaldo Cruz, 87, 1992, pp. 133-136
The determination of amino acid changes in the envelope protein by dir
ect sequencing of either genomic RNA or PCR-amplified cDNA fragments p
rovides useful informations for assessing the genetic variability and
the geographic distribution of the actually most widespread dengue-2 s
erotype. The possible link of variations in the envelope protein-gene
and virus virulence is discussed.