SYNTHETIC STUDIES OF ANTITUMOR MACROLIDE LAULIMALIDE - ENANTIOSELECTIVE SYNTHESIS OF THE C-3-C-14 SEGMENT BY A CATALYTIC HETERO-DIELS-ALDERSTRATEGY

Authors
GHOSH AK MATHIVANAN P CAPPIELLO J
Citation
Ak. Ghosh et al., SYNTHETIC STUDIES OF ANTITUMOR MACROLIDE LAULIMALIDE - ENANTIOSELECTIVE SYNTHESIS OF THE C-3-C-14 SEGMENT BY A CATALYTIC HETERO-DIELS-ALDERSTRATEGY, Tetrahedron letters, 38(14), 1997, pp. 2427-2430
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
14
Year of publication
1997
Pages
2427 - 2430
Database
ISI
SICI code
0040-4039(1997)38:14<2427:SSOAML>2.0.ZU;2-0
Abstract
The C-3-C-14 segment of the novel antitumor agent laulimalide has been constructed enantioselectively by utilizing a catalytic asymmetric he tero Diels-Alder reaction of benzyloxyacetaldehyde and Danishefsky's d iene followed by Ferrier rearrangement and asymmetric conjugate reacti on as the key steps. (C) 1997 Elsevier Science Ltd.