SYNTHESIS OF TRISUBSTITUTED INDOLES ON THE SOLID-PHASE VIA PALLADIUM-MEDIATED HETEROANNULATION OF INTERNAL ALKYNES

Authors
ZHANG HC BRUMFIELD KK MARYANOFF BE
Citation
Hc. Zhang et al., SYNTHESIS OF TRISUBSTITUTED INDOLES ON THE SOLID-PHASE VIA PALLADIUM-MEDIATED HETEROANNULATION OF INTERNAL ALKYNES, Tetrahedron letters, 38(14), 1997, pp. 2439-2442
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
14
Year of publication
1997
Pages
2439 - 2442
Database
ISI
SICI code
0040-4039(1997)38:14<2439:SOTIOT>2.0.ZU;2-Q
Abstract
Palladium-mediated heteroannulation of internal alkynes with resin-bou nd o-iodoaniline derivatives 4 or Sa provided diverse trisubstituted i ndoles 6 in good yields. The facile reaction of trimethylsilylalkynes afforded resin-bound precursors useful for obtaining other 2-substitut ed indole derivatives, such as 12. (C) 1997 Elsevier Science Ltd.