New software for microcomputers enables predictive, quantitative model
s of genetic systems to be produced that can account for the elements
of time, scale, and feedback control of hierarchical systems. The flow
of genetic information during protein synthesis can be addressed by t
reating each intermediate as a kinetic element in a linked series of r
eactions. When the rate of transcription changes, the time required to
achieve a new level of the encoded protein is expected to be a functi
on of the conversion rates or half-lives of all intermediates. Kinetic
modeling may be used to make predictions and integrate primary data c
oncerning rates of transcription, nuclear mRNA dynamics, nucleocytopla
smic transport, translational control, and other processes that govern
the rate of synthesis for specific proteins.