CYTOPLASMIC GPIIB-IIIA AND CYTOKINE SECRETION BY BLASTS IN A CASE OF MEGAKARYOBLASTIC TRANSFORMATION OF ESSENTIAL THROMBOCYTHEMIA

Authors
SELLERI C ALFINITO F DELVECCHIO L LUCIANO L DERENZO A ROTOLI B
Citation
C. Selleri et al., CYTOPLASMIC GPIIB-IIIA AND CYTOKINE SECRETION BY BLASTS IN A CASE OF MEGAKARYOBLASTIC TRANSFORMATION OF ESSENTIAL THROMBOCYTHEMIA, Leukemia & lymphoma, 10(6), 1993, pp. 497-500
Citations number
NO
Categorie Soggetti
Hematology
Journal title
Leukemia & lymphoma → ACNP
ISSN journal
10428194
Volume
10
Issue
6
Year of publication
1993
Pages
497 - 500
Database
ISI
SICI code
1042-8194(1993)10:6<497:CGACSB>2.0.ZU;2-Y
Abstract
A 49-year-old woman with a four year history of therapy resistant esse ntial thrombocythemia, progressed to acute leukemia that also proved r efractory to chemotherapy. Blast cell features including immunophenoty pe, cytogenetics and in vitro cell cultures, suggested megakaryoblasti c leukemia. In serum-free culture, blasts released GM-CSF and IL-6 whi ch sustained autocrine growth and promoted normal myeloid and megakary ocytic colony formation.