INDOLOCARBAZOLES .2. SYNTHETIC STUDIES TOWARDS STAUROSPORINE - AN UNEXPECTED 1,2 MIGRATION OF INDOLOCARBAZOLE NITROGEN RESULTS IN A NOVEL AND POTENT PROTEIN-KINASE-C INHIBITOR

Authors
SHANKAR BB MCCOMBIE SW KIRKUP MP VIET AQ PUAR MS GANGULY AK
Citation
Bb. Shankar et al., INDOLOCARBAZOLES .2. SYNTHETIC STUDIES TOWARDS STAUROSPORINE - AN UNEXPECTED 1,2 MIGRATION OF INDOLOCARBAZOLE NITROGEN RESULTS IN A NOVEL AND POTENT PROTEIN-KINASE-C INHIBITOR, Tetrahedron letters, 34(36), 1993, pp. 5685-5688
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
36
Year of publication
1993
Pages
5685 - 5688
Database
ISI
SICI code
0040-4039(1993)34:36<5685:I.SSTS>2.0.ZU;2-T
Abstract
Attempted transformation of the readily accessible cyclofuransylated i ndolocarbazole (4) Lo a cyclopyranosylated compound related to 1 was e xplored. An unexpected rearranged product (10) was obtained from (9). Compound (10) was converted to (14), a potent PKC inhibitor. The mecha nism of the rearrangement was unraveled with a deuterium labeling expe riment.