THE TRANSFORMATION OF NEOPINONE TO CODEINONE IN MORPHINE BIOSYNTHESISPROCEEDS NONENZYMATICALLY

Authors
GOLLWITZER J LENZ R HAMPP N ZENK MH
Citation
J. Gollwitzer et al., THE TRANSFORMATION OF NEOPINONE TO CODEINONE IN MORPHINE BIOSYNTHESISPROCEEDS NONENZYMATICALLY, Tetrahedron letters, 34(36), 1993, pp. 5703-5706
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
36
Year of publication
1993
Pages
5703 - 5706
Database
ISI
SICI code
0040-4039(1993)34:36<5703:TTONTC>2.0.ZU;2-K
Abstract
Thebaine after vinylether cleavage yields neopinone which exists in a chemical equilibrium with codeinone. It is demonstrated that codeine: NADP oxidoreductase in the presence of NADPH shifts this equilibrium q uantitatively towards codeine.