A COMPARISON IN YOUNG AND ELDERLY SUBJECTS OF THE PHARMACOKINETICS AND PHARMACODYNAMICS OF SINGLE AND MULTIPLE DOSES OF BENAZEPRIL

1 The pharmacokinetics and pharmacodynamics of single and multiple ora l doses of the ACE inhibitor benazepril were investigated in young and elderly normotensive subjects. 2 Following multiple doses the trough concentrations were significantly higher in the elderly and the areas under the plasma concentration-time curves (AUC0-24) were significantl y greater, by approximately 23%. 3 The fall in blood pressure tended t o be greater in the elderly subjects but this is likely to be attribut able to their higher initial blood pressures, although it may reflect the small differences in pharmacokinetics. 4 The age related differenc es in kinetics and dynamics following multiple dosing are quantitative ly similar to those obtained with single doses. However. there appears to be a quantitative difference between benazepril and other ACE inhi bitors in that the age related increases were of a relatively smaller magnitude.