COMPARISON OF THE EFFECTS OF (+ -) CP 96,345 AND L-668,169 ON NEUROKININ RECEPTOR-MEDIATED RESPONSES IN RAT AND GUINEA-PIG ISOLATED-TISSUES/

Authors
RAZZAQUE Z LONGMORE J
Citation
Z. Razzaque et J. Longmore, COMPARISON OF THE EFFECTS OF (+ -) CP 96,345 AND L-668,169 ON NEUROKININ RECEPTOR-MEDIATED RESPONSES IN RAT AND GUINEA-PIG ISOLATED-TISSUES/, Neuropeptides, 25(3), 1993, pp. 169-174
Citations number
15
Categorie Soggetti
Neurosciences,"Endocrynology & Metabolism
Journal title
Neuropeptides → ACNP
ISSN journal
01434179
Volume
25
Issue
3
Year of publication
1993
Pages
169 - 174
Database
ISI
SICI code
0143-4179(1993)25:3<169:COTEO(>2.0.ZU;2-1
Abstract
The effects of (+/-) CP 96,345 and L-668,169 on NK1-, NK2- and NK3-rec eptor mediated contractile responses were compared in guinea-pig and r at isolated smooth muscle tissues. Both (+/-) CP 96,345 and L-668,169 inhibited NK1-mediated responses in guinea-pig ileum (pA2 = 9.3 and 6. 4 respectively) but not in rat bladder (pK(B) = < 6 and < 5.5 respecti vely) consistent with species differences in NK1-receptor pharmacology . Both compounds showed some selectivity in inhibiting NK1-receptor ev oked responses in guinea-pig ileum compared to their inhibitory effect s on NK2-receptor mediated responses in guinea-pig bladder and rat ile um and NK3-mediated responses in guinea-pig ileum and rat portal vein.