COMPARATIVE-STUDY OF MORPHOMETRIC PARAMET ERS AND CYTOFLUOROMETRIC DETERMINATION OF DNA CONTENT IN NUCLEI OF CELLS IN WOMEN WITH DYSPLASIA AND UTERINE CERVICAL-CANCER

The morphometric analysis including measurement of the invasion depth and tumour area has been performed on 75 patients with dysplasia and c linical stage I of cervical cancer. Cytofluorimetric analysis of DNA c ontent in the nuclei of epithelial cells was carried out in 43 specime ns from the same patients. The control group consisted of 6 women. It was established that in case of intraepithelial cancer, DNA content in the cells is positively higher as compared with that in the control a nd in case of severe dysplasia. But in the last case the indices are c onsiderably higher than in control. In early carcinomas with the invas ion depth of 3 mm or less DNA content tended to be higher, while in th e cases between 3 and 5 mm, it decreased, though the data were statist ically insignificant. The evolution changes of DNA content were in clo se correlation with an increase of the tumour area and the invasion de pth.