Vf. Chekhun et al., EXPERIMENTAL SUBSTANTIATION FOR APPLICATI ON OF ELECTROMAGNETIC SHORT-WAVE LENGTH RADIATION AS A MODIFIER OF BIOLOGICAL EFFECT OF CISPLATIN, Eksperimental'naa onkologia, 15(4), 1993, pp. 75-78
Electromagnetic short-wave length radiation (EMR) has been studied for
its role in the modification of biological effects of cisplatin. It i
s shown that cisplatin promoted appearance of current fluctuation thro
ugh the bilayer lipid membrane (BLM). The combined action of EMR and c
isplatin considerably stirred up the current fluctuation through the B
LM. The investigation of,cisplatin effect on the functional state of p
lasma membranes showed that EMR enhanced the cytostatic effect of the
anticancer drug more than twice. Substantial differences between the e
lectrophoretic mobilities of normal and malignant cells after the comb
ined action of cisplatin and EMR were revealed by the method of cell e
lectrophoresis. Thus, by the end of observation the electrophoretic mo
bility of lymphocytes increased by 97 %, and that of lymphoblast cells
- by 49 %. It is supposed that EMR activates transport systems of pla
sma membranes, thus changing the membrane potential and the change of
cell surface (zeta-potential).