EXPERIMENTAL SUBSTANTIATION FOR APPLICATI ON OF ELECTROMAGNETIC SHORT-WAVE LENGTH RADIATION AS A MODIFIER OF BIOLOGICAL EFFECT OF CISPLATIN

Electromagnetic short-wave length radiation (EMR) has been studied for its role in the modification of biological effects of cisplatin. It i s shown that cisplatin promoted appearance of current fluctuation thro ugh the bilayer lipid membrane (BLM). The combined action of EMR and c isplatin considerably stirred up the current fluctuation through the B LM. The investigation of,cisplatin effect on the functional state of p lasma membranes showed that EMR enhanced the cytostatic effect of the anticancer drug more than twice. Substantial differences between the e lectrophoretic mobilities of normal and malignant cells after the comb ined action of cisplatin and EMR were revealed by the method of cell e lectrophoresis. Thus, by the end of observation the electrophoretic mo bility of lymphocytes increased by 97 %, and that of lymphoblast cells - by 49 %. It is supposed that EMR activates transport systems of pla sma membranes, thus changing the membrane potential and the change of cell surface (zeta-potential).