Os. Medvedev et Ea. Gorodetskaya, SYSTEMIC AND REGIONAL HEMODYNAMIC-EFFECTS OF PERINDOPRIL IN EXPERIMENTAL HEART-FAILURE, The American heart journal, 126(3), 1993, pp. 764-769
The effects of converting-enzyme inhibition by perindoprilat (0.5 mg/k
g, intravenously, short-term administration) or perindopril (2 mg/kg,
orally, long-term administration once a day for 21 days) on systemic a
nd regional hemodynamics were studied on a new rat model of heart fail
ure, which was induced by microembolization of coronary vessels by 15
mum plastic microspheres. Cardiac output and regional blood flows were
measured by microsphere technique; the tone of the venous vessels was
determined as mean circulatory filling pressure in conscious, freely
moving rats. Perindoprilat evoked a much more prominent increase in ki
dneys, adrenal glands, intestine, and skin blood flows in embolized ra
ts than in sham-operated rats. The differences between the effects of
long-term treatment with perindopril in sham-operated and embolized ra
ts were highly significant. Mean circulatory filling pressure was decr
eased by short-term and long-term administration of an angiotensin-con
verting enzyme inhibitor. It is concluded that venous vessels could be
one of the target sites for the effects of perindopril-like drugs.