ACUTE-PANCREATITIS - CLINICAL AND THERAPE UTIC STUDY WITH SOMATOSTATIN

A clinical and therapeutical study of 47 patients with the diagnosis o f acute pancreatitis is reported. According to Ranson's criteria patie nts were initially classified as suffering from mild (28) and severe ( 18) acute pancreatitis. Twenty-eight, 11, 7 and 1 patients had biliary , alcoholic, idiopathic and neoplastic causes, respectively, of their conditions. The classification of episodes was made on the basis of cl inical manifestations, biologic investigations, and imaging diagnosis, and is shown in the corresponding tables. The therapeutic profile was a randomized double-blind study: perfused somatostatin (SS) versus pl acebo (P) (physiologic saline 0,9%). The administration of somatostati n in perfusion (250 mcg/h/48 hours) did not improve significantly the parameters used to score the severity, although the mortality rate dec reased significantly (p < 0,05) in the group of patients with the seve re form of the disease.