Bm. Migler et al., SEROQUEL - BEHAVIORAL-EFFECTS IN CONVENTIONAL AND NOVEL TESTS FOR ATYPICAL ANTIPSYCHOTIC DRUG, Psychopharmacology, 112(2-3), 1993, pp. 299-307
Seroquel was compared to clozapine and several other antipsychotic age
nts in tests predictive of antipsychotic activity or extrapyramidal sy
mptoms. In the conditioned avoidance test in squirrel monkeys as well
as several paradigms using apomorphine or amphetamine-induced behavior
al alterations, seroquel displayed the profile of a drug with potentia
l antipsychotic activity. In these paradigms the potency of seroquel w
as somewhat less than clozapine in rodent tests, while the reverse was
true in higher species, i.e. monkeys, cats. In tests designed to eval
uate the propensity to induce EPS or tardive dyskinesia, for example,
the production of dyskinetic reactions in haloperidol-sensitized cebus
monkeys, seroquel displayed a profile similar to clozapine and dispar
ate from typical antipsychotic drugs. In drug-naive cebus monkeys sero
quel sensitized significantly fewer monkeys than haloperidol and the d
yskinetic reactions were of significantly less intensity. It is antici
pated that this novel antipsychotic agent will have a significantly re
duced propensity to produce extrapyramidal symptoms and tardive dyskin
esia than typical antipsychotics.