CYCLIC ETHER ACETAL PLATELET-ACTIVATING-FACTOR (PAF) RECEPTOR ANTAGONISTS .1. 3-PYRIDYL DERIVATIVES

Authors
WHITTAKER M THOMPSON TM SPAVOLD ZM PRICE M MILLER A GALLOWAY WA FRASER F FLOYD CD DRUMMOND AH DAVIDSON AH BOWLES SA BEBBINGTON DS
Citation
M. Whittaker et al., CYCLIC ETHER ACETAL PLATELET-ACTIVATING-FACTOR (PAF) RECEPTOR ANTAGONISTS .1. 3-PYRIDYL DERIVATIVES, Bioorganic & medicinal chemistry letters, 3(8), 1993, pp. 1493-1498
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
8
Year of publication
1993
Pages
1493 - 1498
Database
ISI
SICI code
0960-894X(1993)3:8<1493:CEAP(R>2.0.ZU;2-M
Abstract
A novel series of 2-(3-pyridyl)alkoxy-5-aryltetrahydrofuran PAF antago nists has been identified and the effect of variation of the alkoxy ch ain length, aryl substitution and stereochemistry about the tetrahydro furan ring studied. The optimal compound, opanoxy)-5-(3,4,5-trimethoxy phenyl)tetrahydrofuran (27a), inhibits [H-3]-PAF receptor binding to w ashed human platelet membranes with an IC50 value of 100 nM.