A HIGHLY EFFICIENT SYNTHESIS OF RWJ-47639 - A NOVEL, ORALLY-ACTIVE ANGIOTENSIN-II RECEPTOR ANTAGONIST

Authors
HSI JD MURRAY WV GILL A
Citation
Jd. Hsi et al., A HIGHLY EFFICIENT SYNTHESIS OF RWJ-47639 - A NOVEL, ORALLY-ACTIVE ANGIOTENSIN-II RECEPTOR ANTAGONIST, Bioorganic & medicinal chemistry letters, 3(8), 1993, pp. 1523-1526
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
8
Year of publication
1993
Pages
1523 - 1526
Database
ISI
SICI code
0960-894X(1993)3:8<1523:AHESOR>2.0.ZU;2-Y
Abstract
RWJ 47639 (1), a new, potent and orally active angiotensin II receptor antagonist was synthesized by an efficient three-step process utilizi ng addition of a substituted phenyllithium to an ortho-fluorophenyloxa zoline as the key step.