Si. Goldberg et Xp. Liu, ON THE FUNCTION OF THE 2'-HYDROXYL GROUP IN THE PEPTIDYL-TRANSFER RNATERMINUS DURING ELONGATION IN RIBOSOMAL PEPTIDE BIOSYNTHESIS, Bioorganic & medicinal chemistry letters, 3(8), 1993, pp. 1527-1530
Intramolecular ester amminolysis in 1,2-diglycyloxyethane, which was u
sed in the present study to represent a bis(acyloxy)-tRNA adenylate te
rminus, was found to be so slow (5-10% yield after 8-10 hours at 195-d
egrees) that the likelihood of bis(acyloxy)-tRNA as an intermediate in
the ribosomal peptide biosynthetic process appears to be highly impro
bable.