ON THE FUNCTION OF THE 2'-HYDROXYL GROUP IN THE PEPTIDYL-TRANSFER RNATERMINUS DURING ELONGATION IN RIBOSOMAL PEPTIDE BIOSYNTHESIS

Authors
GOLDBERG SI LIU XP
Citation
Si. Goldberg et Xp. Liu, ON THE FUNCTION OF THE 2'-HYDROXYL GROUP IN THE PEPTIDYL-TRANSFER RNATERMINUS DURING ELONGATION IN RIBOSOMAL PEPTIDE BIOSYNTHESIS, Bioorganic & medicinal chemistry letters, 3(8), 1993, pp. 1527-1530
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
8
Year of publication
1993
Pages
1527 - 1530
Database
ISI
SICI code
0960-894X(1993)3:8<1527:OTFOT2>2.0.ZU;2-O
Abstract
Intramolecular ester amminolysis in 1,2-diglycyloxyethane, which was u sed in the present study to represent a bis(acyloxy)-tRNA adenylate te rminus, was found to be so slow (5-10% yield after 8-10 hours at 195-d egrees) that the likelihood of bis(acyloxy)-tRNA as an intermediate in the ribosomal peptide biosynthetic process appears to be highly impro bable.