SYNTHESIS AND IN-VITRO ANTIBACTERIAL ACTIVITY OF HYGROMYCIN-A ANALOGSMODIFIED AT THE C4' ARYL POSITION

Authors
JAYNES BH COOPER CB HECKER SJ BLAIR KT ELLIOTT NC LILLEY SC MINICH ML SCHICHO DL WERNER KM
Citation
Bh. Jaynes et al., SYNTHESIS AND IN-VITRO ANTIBACTERIAL ACTIVITY OF HYGROMYCIN-A ANALOGSMODIFIED AT THE C4' ARYL POSITION, Bioorganic & medicinal chemistry letters, 3(8), 1993, pp. 1531-1536
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
8
Year of publication
1993
Pages
1531 - 1536
Database
ISI
SICI code
0960-894X(1993)3:8<1531:SAIAAO>2.0.ZU;2-Z
Abstract
A variety of hygromycin A analogs are described which contain modifica tions of or replacements for the natural sugar. Antibacterial activiti es against Serpulina (Treponema) hyodysenteriae, an important animal h ealth pathogen, are reported and indicate that small lipophilic C4' su bstituents serve as useful sugar surrogates in the hygromycin A class.