INDOLOCARBAZOLES .1. TOTAL SYNTHESIS AND PROTEIN-KINASE INHIBITING CHARACTERISTICS OF COMPOUNDS RELATED TO K-252C

Authors
MCCOMBIE SW BISHOP RW CARR D DOBEK E KIRKUP MP KIRSCHMEIER P LIN SI PETRIN J ROSINSKI K SHANKAR BB WILSON O
Citation
Sw. Mccombie et al., INDOLOCARBAZOLES .1. TOTAL SYNTHESIS AND PROTEIN-KINASE INHIBITING CHARACTERISTICS OF COMPOUNDS RELATED TO K-252C, Bioorganic & medicinal chemistry letters, 3(8), 1993, pp. 1537-1542
Citations number
36
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
8
Year of publication
1993
Pages
1537 - 1542
Database
ISI
SICI code
0960-894X(1993)3:8<1537:I.TSAP>2.0.ZU;2-4
Abstract
The condensation of indolo[2,3-a]-carbazole (12) with 2,5-dimethoxytet rahydrofuran derivatives gave cyclofuranosylated compounds (e.g. 13), which were converted via dibromocompounds to the dinitriles (e.g. 25). Hydrolysis, hydrolysis-reduction and thiolysis afforded imides, lacta ms (e.g. 27) and their thio analogs. These compounds were potent inhib itors of the protein kinase C family.