(2R, 4S, -(TETRAHYDRO-4-HYDROXY-5-METHOXY-2-FURANYL)THYMINE - A POTENT SELECTIVE INHIBITOR OF HERPES-SIMPLEX THYMIDINE KINASE

Authors
KIM CU MISCO PF LUH BY TERRY B BISACCHI G MANSURI MM
Citation
Cu. Kim et al., (2R, 4S, -(TETRAHYDRO-4-HYDROXY-5-METHOXY-2-FURANYL)THYMINE - A POTENT SELECTIVE INHIBITOR OF HERPES-SIMPLEX THYMIDINE KINASE, Bioorganic & medicinal chemistry letters, 3(8), 1993, pp. 1571-1576
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
8
Year of publication
1993
Pages
1571 - 1576
Database
ISI
SICI code
0960-894X(1993)3:8<1571:(4--AP>2.0.ZU;2-8
Abstract
A series of thymidine analogues substituted with alkoxy groups on the C-4 position of the furan ring were synthesized. Among these compounds , the methoxy analogue 9 was the most potent inhibitor of herpes simpl ex virus type 1 thymidine kinase.