INSIGHT INTO THE CATALYTIC MECHANISM OF KDO8P SYNTHASE - SYNTHESIS AND EVALUATION OF THE ISOSTERIC PHOSPHONATE MIMIC OF THE PUTATIVE CYCLICINTERMEDIATE

Authors
SHEFFERDEENOOR S BELAKHOV V BAASOV T
Citation
S. Shefferdeenoor et al., INSIGHT INTO THE CATALYTIC MECHANISM OF KDO8P SYNTHASE - SYNTHESIS AND EVALUATION OF THE ISOSTERIC PHOSPHONATE MIMIC OF THE PUTATIVE CYCLICINTERMEDIATE, Bioorganic & medicinal chemistry letters, 3(8), 1993, pp. 1583-1588
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
8
Year of publication
1993
Pages
1583 - 1588
Database
ISI
SICI code
0960-894X(1993)3:8<1583:IITCMO>2.0.ZU;2-C
Abstract
The catalytic mechanism of 3-deoxy-D-manno-2-octulosonate-8-phosphate (KDO8P) synthase from Escherichia coli was investigated on the basis o f synthesis and evaluation of the isosteric phosphonate analogue 6 whi ch mimics the topological and electrostatic properties of the putative cyclic intermediate 5.