SYNTHESIS AND BIOLOGICAL EVALUATION OF A SERIES OF HIV-1 PROTEASE INHIBITORS

Authors
TROVA MP BABINE RE BYRN RA CASSCLES WT HASTINGS RC HSU GC JIROUSEK MR JOHNSON BD KERWAR SS SCHOW SR WISSNER A ZHANG N WICK MM
Citation
Mp. Trova et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF A SERIES OF HIV-1 PROTEASE INHIBITORS, Bioorganic & medicinal chemistry letters, 3(8), 1993, pp. 1595-1600
Citations number
40
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
8
Year of publication
1993
Pages
1595 - 1600
Database
ISI
SICI code
0960-894X(1993)3:8<1595:SABEOA>2.0.ZU;2-#
Abstract
A series of HIV-1 protease inhibitors was prepared and evaluated again st the free enzyme for inhibition properties, and for their anti-viral properties in human T lymphoid cells infected with HIV(IIIB). Compoun ds 12, and 19 are the most potent anti-viral agents prepared in this s tudy and are compared to Ro 31-8959, a compound currently in clinical trials for the treatment of AIDS.