A DIAZINE HETEROCYCLE REPLACES A 6-MEMBERED HYDROGEN-BONDED ARRAY IN THE ACTIVE-SITE OF SCYTALONE DEHYDRATASE

Authors
HODGE CN PIERCE J
Citation
Cn. Hodge et J. Pierce, A DIAZINE HETEROCYCLE REPLACES A 6-MEMBERED HYDROGEN-BONDED ARRAY IN THE ACTIVE-SITE OF SCYTALONE DEHYDRATASE, Bioorganic & medicinal chemistry letters, 3(8), 1993, pp. 1605-1608
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
8
Year of publication
1993
Pages
1605 - 1608
Database
ISI
SICI code
0960-894X(1993)3:8<1605:ADHRA6>2.0.ZU;2-F
Abstract
4-aminoquinazoline II is a fully functional substitute for salicylamid e I as a competitive inhibitor of scytalone dehydratase. Kinetic measu rements demonstrate that both inhibitors bind to the enzyme in their n eutral form, suggesting that the hydrogen-bonded array in I binds to t he enzyme active site as an intact structural element.