HYDRIDE TRANSFER VERSUS ELECTRON-TRANSFER IN THE BAKERS-YEAST REDUCTION OF ALPHA-HALOACETOPHENONES

Authors
ALEIXO LM DECARVALHO M MORAN PJS RODRIGUES JAR
Citation
Lm. Aleixo et al., HYDRIDE TRANSFER VERSUS ELECTRON-TRANSFER IN THE BAKERS-YEAST REDUCTION OF ALPHA-HALOACETOPHENONES, Bioorganic & medicinal chemistry letters, 3(8), 1993, pp. 1637-1642
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
8
Year of publication
1993
Pages
1637 - 1642
Database
ISI
SICI code
0960-894X(1993)3:8<1637:HTVEIT>2.0.ZU;2-8
Abstract
The baker's yeast reduction of alpha-iodoacetophenone gave acetophenon e. Some evidence for a free radical chain process in this reduction wa s obtained by addition of DNB which not only provoked a decrease in th e formation of acetophenone but also allow the appearance of the enzym e-controlled formation of (-)-(R)-2-iodo-1-phenylethanol.