EXCITATORY AMINO-ACID RECEPTOR ANTAGONISTS - SYNTHESIS AND PHARMACOLOGY OF 3-(CARBOXYMETHOXY)ISOXAZOLES DERIVED FROM AMPA

Authors
MADSEN U ANDRESEN L POULSEN GA RASMUSSEN TB EBERT B KROGSGAARDLARSEN P BREHM L
Citation
U. Madsen et al., EXCITATORY AMINO-ACID RECEPTOR ANTAGONISTS - SYNTHESIS AND PHARMACOLOGY OF 3-(CARBOXYMETHOXY)ISOXAZOLES DERIVED FROM AMPA, Bioorganic & medicinal chemistry letters, 3(8), 1993, pp. 1649-1654
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
8
Year of publication
1993
Pages
1649 - 1654
Database
ISI
SICI code
0960-894X(1993)3:8<1649:EARA-S>2.0.ZU;2-R
Abstract
Three acidic amino acids were synthesized using the non-NMDA antagonis t, 3-(carboxymethoxy)-5-methyl-4-isoxazolyl]propionic acid (AMOA), as a lead structure. ,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic a cid (1) was found to be a selective NMDA antagonist, whereas ymethoxy) -5-trifluoromethyl-4-isoxazolyl]propionic acid (2) was shown to be a n on-NMDA antagonist.