SYNTHESIS AND CARDIOTONIC ACTIVITY OF YDROPYRIDAZIN-6-YL)PYRAZOLO[4,3-B][1,4]BENZOXAZINE

Authors
COMBS DW
Citation
Dw. Combs, SYNTHESIS AND CARDIOTONIC ACTIVITY OF YDROPYRIDAZIN-6-YL)PYRAZOLO[4,3-B][1,4]BENZOXAZINE, Bioorganic & medicinal chemistry letters, 3(8), 1993, pp. 1663-1666
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
8
Year of publication
1993
Pages
1663 - 1666
Database
ISI
SICI code
0960-894X(1993)3:8<1663:SACAOY>2.0.ZU;2-M
Abstract
o-2,3,4,5-tetrahydropyridazin-6-yl)pyrazolo[4,3-b] [1,4]benzoxazine (1 ) is prepared in two steps from a precursor of bemoradan (2). The comp ound displays a maximum increase in cardiac force of 256% at 75 mug/kg intravenously in an anesthetized dog model and has an ED50 of 15 mug/ kg.