FIBRINOGEN RECEPTOR ANTAGONISTS CONTAINING A GAMMA-LACTAM GLY-ASP ISOSTERE

Authors
KOTTIRSCH G TAPPARELLI C ZERWES HG
Citation
G. Kottirsch et al., FIBRINOGEN RECEPTOR ANTAGONISTS CONTAINING A GAMMA-LACTAM GLY-ASP ISOSTERE, Bioorganic & medicinal chemistry letters, 3(8), 1993, pp. 1675-1680
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
8
Year of publication
1993
Pages
1675 - 1680
Database
ISI
SICI code
0960-894X(1993)3:8<1675:FRACAG>2.0.ZU;2-6
Abstract
A gamma-lactam bridged Gly-Asp dipeptide isostere was synthesised and incorporated into RGDX tetrapeptides as a replacement for GD to obtain conformationally constrained fibrinogen receptor antagonists.