ROLE OF SULFONAMIDE MOIETY IN NONPROSTANOID TXA(2) RECEPTOR ANTAGONIST KT2-962 - MODIFICATIONS OF THIS MOIETY AND THE RESULTING ACTIVITIES

Authors
YOKOTA M IMAMAKI K UCHIBORI S KONDO M KOSAKAI K TOMIYAMA T
Citation
M. Yokota et al., ROLE OF SULFONAMIDE MOIETY IN NONPROSTANOID TXA(2) RECEPTOR ANTAGONIST KT2-962 - MODIFICATIONS OF THIS MOIETY AND THE RESULTING ACTIVITIES, Bioorganic & medicinal chemistry letters, 3(8), 1993, pp. 1687-1692
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
8
Year of publication
1993
Pages
1687 - 1692
Database
ISI
SICI code
0960-894X(1993)3:8<1687:ROSMIN>2.0.ZU;2-W
Abstract
Modification of sulfonamide moiety in non-prostanoid thromboxane A2 (T XA2) receptor antagonist, KT2-962 with double amide, sulfonamide-amide , (thio)semicarbazone, inverse sulfonamide and N-sulfonylcarboxamide i s described. Unlike prostanoid TXA2 antagonists, the importance of sul fonamide moiety for the activity of non-prostanoid TXA2 receptor antag onist, KT2-962 was confirmed.