TARGETING RADIOSENSITIZERS TO DNA BY MINOR-GROOVE BINDING - NITROARENES BASED ON NETROPSIN AND DISTAMYCIN

Authors
PARRICK J PORSSA M DAVIES LK DENNIS MF PATEL KB STRATFORD MRL WARDMAN P
Citation
J. Parrick et al., TARGETING RADIOSENSITIZERS TO DNA BY MINOR-GROOVE BINDING - NITROARENES BASED ON NETROPSIN AND DISTAMYCIN, Bioorganic & medicinal chemistry letters, 3(8), 1993, pp. 1697-1702
Citations number
33
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
8
Year of publication
1993
Pages
1697 - 1702
Database
ISI
SICI code
0960-894X(1993)3:8<1697:TRTDBM>2.0.ZU;2-H
Abstract
Four analogues of the antitumour antibiotics, netropsin and distamycin , containing 2-nitroimidazole or 5-nitrofuran moieties were synthesise d. All showed high affinity for DNA, including compounds with only one pyrrole/amidine moiety, but the radiosensitizing efficiencies were po or. The results have implications both for minor groove targeting and the design of radiosensitizers.