QUINUCLIDINE BASED NK-1 ANTAGONISTS .2. DETERMINATION OF THE ABSOLUTESTEREOCHEMICAL REQUIREMENTS

Authors
SWAIN CJ SEWARD EM SABIN V OWEN S BAKER R CASCIERI MA SADOWSKI S STRADER C BALL RG
Citation
Cj. Swain et al., QUINUCLIDINE BASED NK-1 ANTAGONISTS .2. DETERMINATION OF THE ABSOLUTESTEREOCHEMICAL REQUIREMENTS, Bioorganic & medicinal chemistry letters, 3(8), 1993, pp. 1703-1706
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
8
Year of publication
1993
Pages
1703 - 1706
Database
ISI
SICI code
0960-894X(1993)3:8<1703:QBNA.D>2.0.ZU;2-4
Abstract
The relative and absolute stereochemical requirements for high affinit y binding to the human NK-1 receptor are defined for a series of quinu clidine ethers. Whilst the S stereochemistry at C-3 is essential for h igh affinity, surprisingly both epimers at C-2 are active.