A NOVEL CLASS OF 1,3-OXATHIOLANE NUCLEOSIDE ANALOGS HAVING POTENT ANTI-HIV ACTIVITY

Authors
BELLEAU B BRASILI L CHAN L DIMARCO MP ZACHARIE B NGUYENBA N JENKINSON HJ COATES JAV CAMERON JM
Citation
B. Belleau et al., A NOVEL CLASS OF 1,3-OXATHIOLANE NUCLEOSIDE ANALOGS HAVING POTENT ANTI-HIV ACTIVITY, Bioorganic & medicinal chemistry letters, 3(8), 1993, pp. 1723-1728
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
8
Year of publication
1993
Pages
1723 - 1728
Database
ISI
SICI code
0960-894X(1993)3:8<1723:ANCO1N>2.0.ZU;2-Q
Abstract
We have developed a novel class of 1,3-oxathiolane nucleoside analogue s which were evaluated for anti-HIV activity in the MT-4 cell line. BC H-371, the adenine derivative. has been found to exhibit significant a nti-HIV activity.