OXAZOLE, THIAZOLE, AND IMIDAZOLE DERIVATIVES OF 2,6-DI-TERT-BUTYLPHENOL AS DUAL 5-LIPOXYGENASE AND CYCLOOXYGENASE INHIBITORS

Authors
UNANGST PC CONNOR DT CETENKO WA SORENSON RJ SIRCAR JC WRIGHT CD SCHRIER DJ DYER RD
Citation
Pc. Unangst et al., OXAZOLE, THIAZOLE, AND IMIDAZOLE DERIVATIVES OF 2,6-DI-TERT-BUTYLPHENOL AS DUAL 5-LIPOXYGENASE AND CYCLOOXYGENASE INHIBITORS, Bioorganic & medicinal chemistry letters, 3(8), 1993, pp. 1729-1734
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
8
Year of publication
1993
Pages
1729 - 1734
Database
ISI
SICI code
0960-894X(1993)3:8<1729:OTAIDO>2.0.ZU;2-U
Abstract
Benzylidene di-tert-butylphenols containing oxazole, thiazole, and imi dazole substituents are dual inhibitors of 5-lipoxygenase and cyclooxy genase with IC50 values < 5 muM. The oxazole and thiazole analogs exhi bit oral antiinflammatory activity.