SYNTHESIS AND EVALUATION OF 3-CARBOXYMETHYL STEROIDS AS INHIBITORS OFHUMAN PROSTATIC STEROID 5-ALPHA-REDUCTASE

Authors
HOLT DA OH HJ ROZAMUS LW YEN HK BRANDT M LEVY MA METCALF BW
Citation
Da. Holt et al., SYNTHESIS AND EVALUATION OF 3-CARBOXYMETHYL STEROIDS AS INHIBITORS OFHUMAN PROSTATIC STEROID 5-ALPHA-REDUCTASE, Bioorganic & medicinal chemistry letters, 3(8), 1993, pp. 1735-1738
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
8
Year of publication
1993
Pages
1735 - 1738
Database
ISI
SICI code
0960-894X(1993)3:8<1735:SAEO3S>2.0.ZU;2-N
Abstract
A series of 3-carboxymethyl steroids has been prepared and assayed in vitro as inhibitors of steroid 5alpha-reductase isolated from human pr ostatic tissue. Potent inhibition was observed with analogs from both androstene and estratriene families. Phosphonic and sulfonic acid anal ogs were also prepared and found to lack significant inhibitory activi ty.