THE SELECTIVE-INHIBITION OF PHOSPHODIESTERASE-IV BY BENZOPYRAN DERIVATIVES OF ROLIPRAM

Authors
PINTO IL BUCKLE DR READSHAW SA SMITH DG
Citation
Il. Pinto et al., THE SELECTIVE-INHIBITION OF PHOSPHODIESTERASE-IV BY BENZOPYRAN DERIVATIVES OF ROLIPRAM, Bioorganic & medicinal chemistry letters, 3(8), 1993, pp. 1743-1746
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
8
Year of publication
1993
Pages
1743 - 1746
Database
ISI
SICI code
0960-894X(1993)3:8<1743:TSOPBB>2.0.ZU;2-Y
Abstract
A series of benzopyran derivatives of rolipram has been prepared, one of which, 8a, proved to be a potent inhibitor of the PDE IV isoenzyme. The enantiomers of 8a were separated and activity shown to reside mai nly in the (+) enantiomer. These novel compounds display much reduced activity on the high affinity form of PDE IV relative to rolipram.