PROTECTIVE EFFECT OF SV-IV ON PLATELET-ACTIVATING FACTOR-INDUCED HYPOTENSION, BRONCHOCONSTRICTION AND GASTRIC-MUCOSAL INJURY

Authors
PERSICO P METAFORA S MANCUSO F CALIGNANO A VENTURELLI A MARINIELLO L PORTA R
Citation
P. Persico et al., PROTECTIVE EFFECT OF SV-IV ON PLATELET-ACTIVATING FACTOR-INDUCED HYPOTENSION, BRONCHOCONSTRICTION AND GASTRIC-MUCOSAL INJURY, European journal of pharmacology, 241(1), 1993, pp. 71-74
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
241
Issue
1
Year of publication
1993
Pages
71 - 74
Database
ISI
SICI code
0014-2999(1993)241:1<71:PEOSOP>2.0.ZU;2-9
Abstract
The inhibitory effect of one of the major proteins secreted by the rat seminal vesicles (SV-IV) on platelet-activating factor (PAF)-induced biological activities was investigated in vivo. SV-IV was found to pre vent dose dependently both hypotension and acute bronchospasm caused b y PAF administration in guinea-pigs. In addition, SV-IV inhibited both PAF- and ethanol-induced gastric mucosal injury in a dose-dependent m anner.