POLYMERIC PRODRUGS - SYNTHESIS, RELEASE STUDY AND ANTIMICROBIAL PROPERTIES OF POLYMER-BOUND ACRIFLAVINE

Authors
PATEL H RAVAL DA MADAMWAR D SINHA TJM
Citation
H. Patel et al., POLYMERIC PRODRUGS - SYNTHESIS, RELEASE STUDY AND ANTIMICROBIAL PROPERTIES OF POLYMER-BOUND ACRIFLAVINE, Die Angewandte makromolekulare Chemie, 245, 1997, pp. 1-8
Citations number
9
Categorie Soggetti
Polymer Sciences
Journal title
Die Angewandte makromolekulare Chemie → ACNP
ISSN journal
00033146
Volume
245
Year of publication
1997
Pages
1 - 8
Database
ISI
SICI code
0003-3146(1997)245:<1:PP-SRS>2.0.ZU;2-I
Abstract
A matrix of poly(methyl methacrylate-co-maleic anhydride) with surface containing functional anhydride groups of different percentage was pr epared by solution polymerization and characterized. Acriflavine was b ound on the surface of this matrix by chemical bonding in organic medi um. The amount of acriflavine chemically bound to the matrix was spect roscopically characterized and the in vitro release rate of acriflavin e in weakly basic medium was established along with the determination of its antimicrobial activity.