VASCULITIS AND ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES ASSOCIATED WITH PROPYLTHIOURACIL THERAPY

Authors
DOLMAN KM GANS ROB VERVAAT TJ ZEVENBERGEN G MAINGAY D NIKKELS RE DONKER AJM BORNE AEGKV GOLDSCHMEDING R
Citation
Km. Dolman et al., VASCULITIS AND ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES ASSOCIATED WITH PROPYLTHIOURACIL THERAPY, Lancet, 342(8872), 1993, pp. 651-652
Citations number
10
Categorie Soggetti
Medicine, General & Internal
Journal title
Lancet → ACNP
ISSN journal
01406736
Volume
342
Issue
8872
Year of publication
1993
Pages
651 - 652
Database
ISI
SICI code
0140-6736(1993)342:8872<651:VAACAA>2.0.ZU;2-N
Abstract
Vasculitis is a rare complication of propylthiouracil therapy. Antineu trophil cytoplasmic antibodies (ANCA) have been described in associati on with several vasculitic disorders. We report detection of ANCA agai nst human neutrophil elastase, proteinase 3, and myeloperoxidase in se rum from six patients who developed evidence of vasculitis during prop ylthiouracil treatment of hyperthyroidism. On withdrawal of the drug A NCA concentrations fell and clinical symptoms resolved completely.