CHANGES IN INSULIN-RECEPTOR, HEXOKINASE AND NADPH PRODUCING ENZYMES IN CHOROID-PLEXUS DURING EXPERIMENTAL DIABETES

The activities of insulin receptor and the enzymes hexokinase (EC 2.7- 1.1) and NADP-dependent malic enzyme (EC 1.1.1.40), glucose 6-phosphat e dehydrogenase (EC 1.1.1.49) and isocitrate dehydrogenase (EC 1.1.1.4 2) were measured in rat choroid plexus in alloxan induced diabetes. A significant decrease was observed in the activities of all the enzymes except isocitrate dehydrogenase and also the choroid plexus insulin r eceptor activity was decreased. A reversal of the effect was observed with insulin administration to diabetic rats. It may be concluded that the enzymes of choroid plexus together with insulin receptor are dire ctly controlled by the concentration of insulin.