P. Sebert et al., EFFECT OF GAMMA-IRRADIATION ON HYDROXYPROPYLMETHYLCELLULOSE POWDERS -CONSEQUENCES ON PHYSICAL, RHEOLOGICAL AND PHARMACOTECHNICAL PROPERTIES, International journal of pharmaceutics, 99(1), 1993, pp. 37-42
In this paper, we describe a number of hydroxypropylmethylcellulose (H
PMC) powders which were subjected to gamma-irradiation and report the
results obtained following investigation of their physical properties
(coloration, UV and IR spectrometry, calorimetry) and rheological beha
viour. The physical properties were not significantly modified on incr
easing the irradiation dose. In contrast, the rheological behaviour of
the HPMC powders was modified: firstly, the solutions displayed pseud
o-plastic behaviour, becoming Newtonian on rupture of the chains with
increase in the irradiation dose. Concurrently to this polymeric trans
formation, the viscosity of the solutions decreased. HPMC powders, irr
adiated at different doses, were used in solution as a binding agent f
or granulation during tablet manufacture. The different production sta
ges are also described, as well as physical controls (mass, friability
, hardness, disintegration) dissolution tests of the active substance
from the tablets. No clear modification can be noted.