THE IONIZATION PROPERTIES OF ACYCLOVIR AND DEOXYACYCLOVIR

Authors
KRISTL A MRHAR A KOZJEK F
Citation
A. Kristl et al., THE IONIZATION PROPERTIES OF ACYCLOVIR AND DEOXYACYCLOVIR, International journal of pharmaceutics, 99(1), 1993, pp. 79-82
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
99
Issue
1
Year of publication
1993
Pages
79 - 82
Database
ISI
SICI code
0378-5173(1993)99:1<79:TIPOAA>2.0.ZU;2-9
Abstract
The ionisation constant pK(a) for N2-acetylacyclovir was determined by a spectrophotometric method. The value obtained for pK(a) of N2-acety lacyclovir and previously reported pK(a) values (Kozjek et al., Acta P harm. Jugosl., 38 (1988) 61-69; Kristl et al., Int. J. Pharm., 57 (198 9) 229-234.) for acyclovir and deoxyacyclovir were compared with the a im of locating basic and acidic moieties in the molecules.