EFFECTS OF SENNOSIDES ON CELLULAR ELECTRI C-ACTIVITIES IN SMOOTH-MUSCLE CELLS OF GUINEA-PIG TAENIA-COLI

Authors
YANG WX JIN ZG XU WS TIAN ZS GUO SD
Citation
Wx. Yang et al., EFFECTS OF SENNOSIDES ON CELLULAR ELECTRI C-ACTIVITIES IN SMOOTH-MUSCLE CELLS OF GUINEA-PIG TAENIA-COLI, Zhongguo yaoli xuebao, 14(5), 1993, pp. 430-432
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Zhongguo yaoli xuebao → ACNP
ISSN journal
02539756
Volume
14
Issue
5
Year of publication
1993
Pages
430 - 432
Database
ISI
SICI code
0253-9756(1993)14:5<430:EOSOCE>2.0.ZU;2-C
Abstract
The effects of sennosides (Sen, an extract of Chinese rhubarb) on cell ular spontaneous electric activities of guinea pig taenia coli were st udied by intracellular microelectrode technique. Sen 0.1-20 mmol . L-1 improved the depolarization of cell membrane, quickened the burst of slow wave potential, and increased notably the frequency of spike pote ntials. Sen (20 mmol.L-1) induced spontaneous spike potentials. These results provide direct evidence for the enhancing effect of Sen on int estinal peristalsis at cellular level.