INCLUSION-COMPOUNDS OF CHOLESTEROL AND BETA-CYCLODEXTRIN

By using H-1-NMR spectroscopy X-ray diffractometry, heat of fusion det erminations and contact angle measurements, the formation of two inclu sion compounds between cholesterol and beta-cyclodextrin of different molar ratios was demonstrated. The preparation of the inclusion compou nds was performed by shaking aqueous suspensions of cholesterol and di fferent amounts of dissolved beta-cyclodextrin. A cholesterol/beta-cyc lodextrin inclusion compound having a molar ratio of 1:2 was obtained at lower beta-cyclodextrin concentrations (e.g. 2.2 . 10(-3) M), anoth er one of having a ratio of 1:3 was obtained at higher beta-cyclodextr in concentrations (13.2 . 10(-3) M.