Total body I-131 scanning done on a 67-year-old woman with thyroid can
cer revealed abnormal tracer uptake within the mid-thorax, thought to
represent metastasis in the mediastinum or thoracic spine. Single-phot
on emission computed tomography images of the thorax showed contiguity
between the thoracic uptake and the normal, physiologic uptake of rad
ioiodine in the stomach, suggesting physiologic accumulation within a
hiatal hernia. To confirm the alimentary tract location of the radioio
dine, a study using orally administered Tc-99m SC in water was perform
ed. The images were similar to the iodine images and revealed a patter
n consistent with hiatal hernia. A hiatal hernia was also observed as
an incidental finding on chest radiographs and an MRI. This case illus
trates the potential for an abnormal anatomic configuration to mimic m
etastatic thyroid cancer and shows how SPECT and oral Tc-99m SC images
may be useful in making this distinction.