PRELIMINARY TL-201 SPECT FOR ASSESSMENT OF TREATMENT EFFICACY IN 3 PATIENTS WITH PANCREATIC-CANCER

To evaluate treatment efficacy, Tl-201 SPECT was performed in three pa tients with pancreatic cancer. In all of the patients, the degree of T l-201 uptake by tumor, evaluated from the tumor-liver uptake ratio of Tl-201 activity, correlated well with alterations in serum level of a tumor marker (CA 19-9, DUPAN-2) after treatment. One of the patients s howed no tumor shrinkage on CT after treatment; however, Tl-201 SPECT demonstrated reduced uptake in the tumor coupled with a decreased leve l of CA 19-9. These results suggest that Tl-201 SPECT may become a new tool for assessing the efficacy of treatment in pancreatic cancer.