SIGNAL-TRANSDUCTION IN TRYPANOSOMA-CRUZI - OPPOSITE EFFECTS OF ADENYLCYCLASE AND PHOSPHOLIPASE-C SYSTEMS IN GROWTH-CONTROL

Authors
OLIVEIRA MM ROCHA ED RONDINELLI E ARNHOLDT AV SCHARFSTEIN J
Citation
Mm. Oliveira et al., SIGNAL-TRANSDUCTION IN TRYPANOSOMA-CRUZI - OPPOSITE EFFECTS OF ADENYLCYCLASE AND PHOSPHOLIPASE-C SYSTEMS IN GROWTH-CONTROL, Molecular and cellular biochemistry, 124(2), 1993, pp. 91-99
Citations number
29
Categorie Soggetti
Biology
Journal title
Molecular and cellular biochemistry → ACNP
ISSN journal
03008177
Volume
124
Issue
2
Year of publication
1993
Pages
91 - 99
Database
ISI
SICI code
0300-8177(1993)124:2<91:SIT-OE>2.0.ZU;2-O
Abstract
Fetal calf serum (FCS), which is mitogenic for the pathogenic protozoa T. cruzi, inhibits cAMP production in basal and forskolin-stimulated epimastigotes. It also activates phosphoinositides hydrolysis yielding diacylglycerol and inositol phosphates (Ins-P). Ins-P production is e nhanced by AlF4-, GTP or beta-gamma-methylene-GTP, thus implying G pro teins mediation in the phenomenon. An enzyme with phospholipase C acti vity which may be involved in the phospholipid metabolism was partiall y characterized.